Though Ubisoft’s announcement stops short of confirming the new announcement will be a direct sequel to Wildlands – there were all kinds of Ghost Recon games before Wildlands brought the series into the open-world fold – it will likely tie in somehow. Wildlands was a commercial success and Ubisoft has been leaning hard into open-world games, so I doubt Ubisoft would be quick to point the series back toward a sequential line of single-player missions or strategy spinoffs.
I dream that a followup to Ghost Recon Wildlands would take the game deeper into the weird territory it started exploring in that limited-time Predator crossover mission. Imagine finding out that all of the drug cartels you were hunting in the first game are actually run by aliens, giving your squad no choice but to team up with Earthling cryptids like Bigfoot and the Chupacabra to take them down. It could still happen, I guess. Who’s to say Skell Tech hasn’t secretly been an extraterrestrial shell corporation this whole time?